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pentobarbital will lessen the extent or result of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or result of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will lessen the level or result of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
Induction of microsomal enzymes by this drug, may possibly shorten the 50 %-life of doxycycline for so long as 2 months soon after barbiturate therapy discontinued; monitor medical response to doxycycline carefully if each medicine administered concurrently
Barbiturates might cause fetal harm when administered into a pregnant lady; retrospective, circumstance-controlled studies have proposed a connection involving maternal usage of barbiturates and the next-than-anticipated incidence of fetal abnormalities
[2] Studies have shown the superiority of pentobarbital resulting from its more rapidly brain penetration and shorter half-life, thus which makes it the preferred treatment for refractory status epilepticus.
pentobarbital will lessen the extent or influence of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will minimize the extent or outcome of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers can result in diminished serum concentrations and loss of antimalarial efficacy
pentobarbital will lessen the level or influence of montelukast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will decrease the level or impact of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the extent or outcome of fosphenytoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.
pentobarbital will lower the level or effect of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. The efficacy of hormonal contraceptives can be lowered. Use of a nonhormonal contraceptive is recommended.
pentobarbital will lower the level or outcome of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Pentobarbital interacts with numerous important classes of prescription drugs and demands shut monitoring to keep up therapeutic drug levels. As a class, barbiturates induce hepatic microsomal enzymes, which enhance the price of metabolism of website other medicine metabolized by these hepatic enzymes.